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sadiesnana 11-07-18 02:31 PM

My grandsons diagnosis
 
Just found out yesterday that my 25 year old Grandson has the huntington gene I think he is already showing symptom's have done for a while but my daughter won't have it she just's keep's saying he is to young I've read online that some people can get symptoms earlier is that true x

Allan 12-07-18 11:44 AM

Re: My grandsons diagnosis
 
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Hi there

My son was also diagnosed with HD at 25 - with a CAG repeat count of 56. He had been showing Behavioural and Movement issues for quite a while.

It seems that the beginnings of HD can have different starting points for each individual. The Neurologist will always refer to family history and how the mutant gene may have transferred down to your grandson. It’s not an easy question to answer here without having more family details. From the little info that you give it might seem that the disease could be on his father’s side of the family. If that’s the case then the age of the father at your grandson’s birth could, possibly, influence the onset of "early symptoms" in your grandson.

It is written that older fathers have changes in their sperm content as they grow older, causing the mutant gene to expand, whereas the egg, waiting to be fertilised, has been ready, in the same state for many years.

So, with earlier onset of symptoms you might possibly observe “behavioural and emotional” issues earlier than movement disorder and cognitive problems.

“[I]Symptoms, such as low mood, are experienced objectively but cannot be observed, while disease signs like chorea are apparent on examination. Signs and symptoms often go hand-in-hand, but this is not always the case. Some HD expansion carriers have clear motor abnormalities but report no symptoms; more commonly, subjective complaints of cognitive and affective symptoms precede motor onset[/I].”

[URL="http://discovery.ucl.ac.uk/1447184/6/Wild_UCL%20Chapter%205%20-%20Wild%20and%20Tabrizi%202013-07-24.pdf"][COLOR="Blue"][U][B]Premanifest and Early Huntington’s Disease[/B][/U][/COLOR][/URL]

If you feel that you want to learn more about JHD (under 20) and young onset HD (over 20) I found it very useful to read through the following handbook - and many others. This gave me a solid background from where I could “see where it all started” and know what had to be done, family-wise, for the ongoing care of my son.

[URL="http://hdsa.org/wp-content/uploads/2015/03/Juvenile-HD-Handbook_2nd-Edition.pdf"][COLOR="blue"][U][B]The Juvenile HD Handbook - A Guide for Families and Caregivers[/B][/U][/COLOR][/URL]

Best wishes …

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Zlmd2017 22-07-18 02:49 PM

Re: My grandsons diagnosis
 
I'm very sorry to hear of your grandsons diagnosis that is extreamly painful i have a grandson of 2 and a son of 21 so for me this situation is close to my heart I am constantly looking for signs and I know all the facts and all the medical side but the emotional side is tough I send you lots of love hope and courage and I wait in hope that the proffessors lead us to medication or indeed a cure to this horrible spiteful disease xx

Gabby 29-07-18 07:33 PM

Re: My grandsons diagnosis
 
[QUOTE=sadiesnana;67297]Just found out yesterday that my 25 year old Grandson has the huntington gene I think he is already showing symptom's have done for a while but my daughter won't have it she just's keep's saying he is to young I've read online that some people can get symptoms earlier is that true x[/QUOTE]

Hi sadiesnana
You say he has the gene so I assume he has had a genetic test ?
normally they will say if it is a pre-symptomatic test or not .
He should be under a genetics clinic or a neurologist as well as his GP and they will say when he is symptomatic based on Physical movements / twitches .
as others have said it is possible so his age is not a fall proof guide that he is not symptomatic .
It could be your daughter doesn't want to face the fact or what you are seeing are not symptoms its Hard to tell , what sort of things make you think he already has symptoms .?Bearing in mind he could be suffering with depression just knowing he has tested positive .

Take Care
Gabby


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