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Old 09-08-18, 02:09 PM   #1
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Default Seizures

Hi Everyone

Has anyone had any experiences of seizures in adult HD, I would be grateful for any advise.
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Old 10-08-18, 12:03 PM   #2
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Default Re: Seizures

Hi there

As you are probably aware seizures are more commonly seen in Juvenile HD. However, if you do a search for "seizure" by clicking on Search up above you will find a number of posts mainly related to one solitary example of "seizure" in adult HD. This case was examined and written up here: Psychogenic non-epileptic seizures in early Huntington’s disease

The following paper is difficult to manage in places (due to content) and it also suggests that there isn't a single prescriptive title yet :

"As yet there is no consensus on terminology, with non-epileptic attack disorder, psychogenic non-epileptic seizures (PNES), functional seizures, dissociative seizures all in current usage."

Non-epileptic attack disorder: the importance of diagnosis and treatment

The following paragraphs, although they don’t mention seizures, are said to be similar in what they include for most neurodegenerative diseases:

“Besides resting tremor, bradykinesia, stiffness, and postural instability, in PD patients the occurrence of non-motor symptoms appears particularly relevant. Several reports described a large number of visceral alterations in PD patients. These non-motor symptoms include autonomic (gastrointestinal, cardiovascular, urinary and sexual dysfunctions; hyperhidrosis), sleep (impaired sleep initiation and maintenance, rapid eye movement disorder, excessive daytime sleepiness), sensory (pain, hyposmia, visual dysfunction), as well as neuropsychiatric (anhedonia, depression, anxiety, panic attacks, dementia, and psychosis) disorders. In particular, constipation, orthostatic dizziness, hyposmia, rapid eye movement disorder and depression are the most frequent symptoms that can anticipate the motor impairment. Some studies indicated that constipation occurs in PD patients by an average of 10 years or longer before the onset of motor symptoms.”

“Neurodegenerative diseases (NDs) include a large variety of disorders that affects specific areas of the central nervous system, leading to psychiatric and movement pathologies. Non-motor alterations also occur in several viscera, in particular the gastrointestinal tract and they often precede the onset of motor symptoms by several years. For this reason, dysautonomic changes can be predictive of NDs and their correct recognition being a remarkable importance. This peculiar feature led to the concept that neurodegeneration may initiate in the periphery and propagate retrogradely towards the central nervous system in a prion-like manner. In recent years, a particular attention was dedicated to the clinical assessment of autonomic disorders in patients affected by NDs.”

The neurobiology of dysautonomia in Parkinson’s disease

Autonomic Symptoms in Huntington’s Disease

I think what I’m suggesting is that because of all that can happen in an HD person’s day/life these “seizures”, “stoppages”, “non-displays”, etc might not be noticed by others as too-much-out-of-the-ordinary in an HD person’s daily life - and, therefore, they are very much under-reported to GPs and Neurologists. I could be very wrong.

Best wishes ...

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