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Old 03-07-15, 12:00 AM   #1
frankie
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Default Olanzapine

Hi to old friends and new.

I need some expert advice. My sibling has been on Citalopram for 3 years now.
Depression and mood had been manageable. There was a dramatic change 2 months ago in both mood and depression . He said he felt as though he was overflowing with sadness and anxiety. I automatically thought we could increase the Citalopram , but GP said we can't go above 40mg now.

A few months ago he'd been prescribed Olanzapine by the community psychiatrist who he see's for "depression ", to help him sleep.
I was shocked when I read it was an antipsychotic and decided not to give it him as he has no psychiatric problems and is astute and bright as a button.

With this sudden change in mood I looked into the Olanzapine again and had advice from a RCA who said the side effects were good for HD, the increase in appetite being one.

I decided it was worth trying as he was getting lower and more depressed . He started a low dose of 2.5 and initially I was pleased as he was definitely hungry (which was unusual and a joy to see ) but it was short lived. He has been having more falls and mood is as low as ever. I read more into the drug and if it is going to work the anxiety and depression go in days and this hasn't happened.

I feel I need to get him off it asap and try something else.
Does anyone know if we have to withdraw slowly if it has only been 2.5 for just over a week and can you suggest anything else worth trying to lift this depression ?

I have to suggest things to the GP or community psychiatrist as he won't see anyone connected with "that thing " HD.

Thank you in advance.
From one heartbroken sister. xx
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Old 03-07-15, 04:11 AM   #2
Cupcake
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Default Re: Olanzapine

Hi Frankie

So sorry to read your post and the other ones, it never rains unless it pours in our HD world.

In my experience with the Olanzapine it is a low dosage and not really into the system yet, and usually works after 2 weeks, it is very low dose and it can be increased to as much as 20mg. It is a modern drug and also helps with chorea That said M was on it and went to the full dose 18 mths ago, when it seemed it did not work anymore, he has tried nearly everything on list that is included by the fact sheets on the HD site, I would suggest you take that to your GP there are so many different ones, it also includes the max dosage, the citalopram it says 60mg is the max, I wonder why GP does not want to go to that? The venlafaxine worked very well for a time. He is now on something which has gone right out of my head and not on the list, and as he is in hospital they are not here along with a mood stabiliser lamotragine, and lorezapan 1mg a day for anxiety. It is so difficult. You will be fine just stopping the Olanzapine, as he has not been on it for long, with all the nightmares I have had with all these awful drugs especially halipirdol, I would say follow your heart, there will be a depressant that works for him.

I myself tried citalopram, it did not work for me and moved to Fluoxetine and that is really good and takes away my anxiety, that said it is not working great at the moment and the GP did suggest increase to 40mg.
Good luck xxxxxx
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Old 04-07-15, 01:07 AM   #3
frankie
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Default Re: Olanzapine

Quote:
Originally Posted by Cupcake View Post
Hi Frankie

So sorry to read your post and the other ones, it never rains unless it pours in our HD world.

In my experience with the Olanzapine it is a low dosage and not really into the system yet, and usually works after 2 weeks, it is very low dose and it can be increased to as much as 20mg. It is a modern drug and also helps with chorea That said M was on it and went to the full dose 18 mths ago, when it seemed it did not work anymore, he has tried nearly everything on list that is included by the fact sheets on the HD site, I would suggest you take that to your GP there are so many different ones, it also includes the max dosage, the citalopram it says 60mg is the max, I wonder why GP does not want to go to that? The venlafaxine worked very well for a time. He is now on something which has gone right out of my head and not on the list, and as he is in hospital they are not here along with a mood stabiliser lamotragine, and lorezapan 1mg a day for anxiety. It is so difficult. You will be fine just stopping the Olanzapine, as he has not been on it for long, with all the nightmares I have had with all these awful drugs especially halipirdol, I would say follow your heart, there will be a depressant that works for him.

I myself tried citalopram, it did not work for me and moved to Fluoxetine and that is really good and takes away my anxiety, that said it is not working great at the moment and the GP did suggest increase to 40mg.
Good luck xxxxxx
Hi CC, thank you so much for your advice when you already have more than enough to bear .

The GP said they don't prescribe Citalopram over 40mg now as it can cause heart problems.

I didn't realise the Olanzapine took a couple of weeks to work , or that it helped with chorea. That seems to be particularly bad at present.

I'm so confused I'll spend the next couple of days investigating . It feels like such a huge burden having to make these decisions and worrying you may be causing more harm than good. I always remember one of the specialists at the AGM saying to try not to give more than one drug at a time as the brain already has so much stuff going on.
My GP suggested venlafaxine and also another one beginning with an M. I will check the fact sheet and also consider giving the Olanzapine a chance. I remembered Haliperdol is a bad one and can cause some dreadful problems.

I am not surprised your AD isn't helping you much at present. Good grief , you're going through an absolute nightmare with M being so poorly.
Bless him CC , it is so unfair.
Take care and I will check in to see how you all are . Good luck at your GP appointment. xxx
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Old 06-07-15, 06:27 AM   #4
banda
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Default Re: Olanzapine

Hi, hubby has been on 2.5mg olanzapine for almost a year and it is a real help. It has reduced the chorea significantly, he is calm and his appetite is very much better and he has gained some weight. Difficult to recall but I think it took about a month or so to impact. The only possible negative, although it may be the hd is that he seems now to nap a bit more during the day. It is all he takes hd related although he does have a couple of blood pressure tabs too.
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Old 06-07-15, 11:01 AM   #5
shiraz
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Default Re: Olanzapine

Hi Frankie

I'm in the camp that sings the praises of Olanzapine because here it has been like a wonder drug. It has "controlled" mood/paranoia/mania etc., and had a positive effect on the chorea and allowed a more peaceful bedtime - no more flaying arms and legs. I recall it taking a couple of weeks to have any noticeable affect and the dosage has been upped from 2.5 to 5 to 10mg. As with all drugs it is trial and error though and what works for one wont be right for another - but with them all you need to give it a bit of time. Hubs has been on a couple of others - one that just didn't do anything and another that made him extremely depressed. This one works for "us" at the moment at least!!

Don't be heartbroken though sister - that makes me feel sad. You'll find a way through, just takes time
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Old 17-07-15, 01:32 PM   #6
frankie
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Default Re: Olanzapine

Thank you all so much for your advice, I really appreciate your help.

I feel that I have made things much worse .

I had the community psychiatrist call in this week to see him and told her the Olanzapine hadn't lessened my brothers depression .

She said to stop it as it is only 2.5mg and won't affect him , to swap the 40mg Citalopram to 20mg until she gets the GP to prescribe Sertraline.

I did as she said on Wednesday , stopped the Olanzapine and only gave brother 20mg Citalopram . He was fine on Wednesday night.

The psychiatrist rang again Thursday morning and said not to drop Citalopram to 20mg after all , and keep it at 40mg until we get the sertraline .
So to sum up he had 2 days of stopping Olanzapine abruptly and a half drop of Citalopram which he has been taking for 5 years.

I picked him up and bought him to my house for tea and he had the most awful chorea, he hasn't had it like that ever before . I rushed him home and gave him the 40mg Citalopram in the hope it will settle it and the change in meds has caused it. I haven't seen him yet today .

I emailed the HD specialist last night , who has been wonderful , (but my brother won't see him as it's HD ) and asked his advice. He hasn't got back to me yet.

From reading what you have said I think I should have stayed as we were on the Citalopram and given the Olanzapine a chance.

I just hope he goes back to not having these movements .
What do you think guys ? Wish I could wrap him up in cotton wool.

Thanks so much xx
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Old 17-07-15, 02:22 PM   #7
Amanda Stansfield
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Default Re: Olanzapine

Quote:
Originally Posted by frankie View Post
Hi CC, thank you so much for your advice when you already have more than enough to bear .

The GP said they don't prescribe Citalopram over 40mg now as it can cause heart problems.

I didn't realise the Olanzapine took a couple of weeks to work , or that it helped with chorea. That seems to be particularly bad at present.

I'm so confused I'll spend the next couple of days investigating . It feels like such a huge burden having to make these decisions and worrying you may be causing more harm than good. I always remember one of the specialists at the AGM saying to try not to give more than one drug at a time as the brain already has so much stuff going on.
My GP suggested venlafaxine and also another one beginning with an M. I will check the fact sheet and also consider giving the Olanzapine a chance. I remembered Haliperdol is a bad one and can cause some dreadful problems.

I am not surprised your AD isn't helping you much at present. Good grief , you're going through an absolute nightmare with M being so poorly.
Bless him CC , it is so unfair.
Take care and I will check in to see how you all are . Good luck at your GP appointment. xxx
Chris is on Olanzapine 10mg and has been for about 6 years now, he really needed something to help with his chorea and aggression along with loads of family issues going on around him at the time. Hes doing good at the moment but i'm putting that down to the fantastic care hes getting at Church Walk.
Olanzapine has its side effects one of which is weight gain but Chris needed to put a few pounds on.

The one begining with M was probabaly Mirtazapine (anti depressant) x

Its all so s**t CC im right there with yoiu x big deep breath
As for wrapping him in cottonwool I wish I could do the same i really really do xxx
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Old 17-07-15, 04:17 PM   #8
shiraz
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Default Re: Olanzapine

Hi Frankie

It's impossible really to say what you should do regards administering drugs because what works for one won't necessarily work for another. All these things do need a bit of time. Hubs is on Olanzapine like I've said and it has reduced his chorea type symptoms, helped him have a more restful sleep (he no longer flays his arms and legs about which just used to fly up in the air and come down with an almighty bang throughout the night whilst he was asleep) and it has totally altered his mood. He was paranoid, manic at times etc., and impossible to calm down or get through to. It was at least a couple of weeks before there was any sign of improvement and the dose was quickly increased to the current 10mg daily, which still seems to be holding things at bay.

All you can do is go with your gut feeling and listen to what the HD specialist says. It's worked for us - or rather "helped", nothing is a cure all
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Old 18-07-15, 12:42 AM   #9
Cupcake
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Default Re: Olanzapine

Hi Frankie

Sorry it's all up and down, and hoping he settles over the weekend. Trouble with medication any slight adjustment seems to have a downward effect. It is always difficult when they swap things, when they have adjusted hubby's meds it has usually meant up to 2 weeks of disaster, whilst the adjustments take place. Hope they sort it soon, keep strong you are doing a great job supporting Chris. Xxxxx
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Old 10-07-18, 08:50 AM   #10
Amanda Stansfield
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Default Re: Olanzapine

Quote:
Originally Posted by frankie View Post
Hi to old friends and new.

I need some expert advice. My sibling has been on Citalopram for 3 years now.
Depression and mood had been manageable. There was a dramatic change 2 months ago in both mood and depression . He said he felt as though he was overflowing with sadness and anxiety. I automatically thought we could increase the Citalopram , but GP said we can't go above 40mg now.

A few months ago he'd been prescribed Olanzapine by the community psychiatrist who he see's for "depression ", to help him sleep.
I was shocked when I read it was an antipsychotic and decided not to give it him as he has no psychiatric problems and is astute and bright as a button.

With this sudden change in mood I looked into the Olanzapine again and had advice from a RCA who said the side effects were good for HD, the increase in appetite being one.

I decided it was worth trying as he was getting lower and more depressed . He started a low dose of 2.5 and initially I was pleased as he was definitely hungry (which was unusual and a joy to see ) but it was short lived. He has been having more falls and mood is as low as ever. I read more into the drug and if it is going to work the anxiety and depression go in days and this hasn't happened.

I feel I need to get him off it asap and try something else.
Does anyone know if we have to withdraw slowly if it has only been 2.5 for just over a week and can you suggest anything else worth trying to lift this depression ?

I have to suggest things to the GP or community psychiatrist as he won't see anyone connected with "that thing " HD.

Thank you in advance.
From one heartbroken sister. xx
hi sweetie

there are many different antipsychotics and antidepressants out there and its dam hard finding the right combination for each person. Mt brother is on 40mg citalopram and 20mg olanzapine and its been the best combination for him.
Now he is in the final stages and sleeps more than ever but he appears comfortable and content with very little movements anymore.
At first the medications made him sleepy but with time he became more animated again.
The thing with medications they can take quite a few weeks to make a difference and your hubby is only on a small dose.
Contact your hubbys HD consultant he/she should be the one prescribing for you x I hope this helps a little. I'll be thinking of you.



" life isn't about waiting for the storm to pass, its about learning how to dance in the rain "
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