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Research, drugs, treatment, new diagnosis Forum for medical issues, and for the recently diagnosed (and families)

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Old 15-10-13, 12:11 AM   #1
Lorraine
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Default MTM-HD: Multiple Tissue Molecular Signatures in Huntington’s Disease

Is anyone else else on this research program??

Ive just had a chunk of muscle taken out of my thigh with no anesthetic!!!

At the time i felt like i was in a torture chamber!!

Now im just glad they have some skin fat and the all important muscle to grow on in the lab and share with other scientists.

Nice juicy piece of HD flesh with a CAG of 44 will aid the testing of various chemicals/processes which the poor R2/6 mouse just wont quite be realistic enough for.....

Lorraine
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Old 15-10-13, 08:14 AM   #2
Trish
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Default Re: MTM-HD: Multiple Tissue Molecular Signatures in Huntington’s Disease

Quote:
Originally Posted by Lorraine View Post
Is anyone else else on this research program??

Ive just had a chunk of muscle taken out of my thigh with no anesthetic!!!

At the time i felt like i was in a torture chamber!!

Now im just glad they have some skin fat and the all important muscle to grow on in the lab and share with other scientists.

Nice juicy piece of HD flesh with a CAG of 44 will aid the testing of various chemicals/processes which the poor R2/6 mouse just wont quite be realistic enough for.....

Lorraine
Hi Lorraine

Not had involvement in that (I'm an ex carer and not HD patient) but wanted to say a HUGE THANKS for taking part!

How come they didn't give you a local anaesthetic?

According to their site see HERE for link yu should have not needed to feel any pain.

'Your second visit to NHNN will be to have the biopsy. This visit starts early in the morning and may require that you stay a night in a London hotel in order to get here on time. You will have similar assessments and checks to the screening visit and further bloods taken, around 80-90mls. We will also take a buccal swab, which is pain free and involves a cotton bud swab being swept around the inside of your mouth for ten seconds. Following this the surgeon will carry out a tissue biopsy from your upper left thigh. This involves injecting a local anaesthetic around the area which will prevent you from feeling any pain.
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Old 15-10-13, 10:49 AM   #3
Lorraine
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Default Re: MTM-HD: Multiple Tissue Molecular Signatures in Huntington’s Disease

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Originally Posted by jacqueline View Post
Hi Lorraine
Thank you so much for taking part.

Dr Ed Wild was saying at the AGM that muscle tissue is one of the most painful biopsies to have. He went on to explain that skin and tissue around the muscle can be numbed but not the actual muscle itself. He said though that it is badly needed for research.

You are a very brave lady indeed.

I asked him had he had it done and said no very sheepishly.

He has had the lumbar punch though with photos to prove it.

Perhaps a double whiskey or two may have helped Lorraine. Even a pre-med where you don't care either way.
I am pretty sure that something should have helped.
You poor thing but at least its all the name of HD and science.
Hi girls,

you couldnt have a pre med as i live in Plymouth and had to get the train home 2 hours after the biopsy....

and they cant anaesthetise the muscle as the cells die.... apparently this happens with all ops but the body renews the cells very quickly and sheds the dead ones.... of course with a piece being grown on in a culture the cells have to be in tip top condition to enable the best chance of success...

id like to find someone else on here who has had it done to compare notes!!

Let me know if you come accross anyone..

L
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