Cag question? - Page 2

B · 27-05-12, 10:39 PM

Hi all,

Thanks for your comments, this seems a very grey area if you ask me!

I'm asking as I was puzzled thinking that surely the Cag can't go down from generation to generation but wasn't 100% sure.

But thanks for all your comments.

Best wishes to you all

B

just1moreperson · 27-05-12, 11:45 PM

Quote:

Originally Posted by B

Hi all,

Thanks for your comments, this seems a very grey area if you ask me!

I'm asking as I was puzzled thinking that surely the Cag can't go down from generation to generation but wasn't 100% sure.

But thanks for all your comments.

Best wishes to you all

B

Very much a grey area, researchers are still learning a lot about CAG repeats and also what other genes or environmental factors impact on HD.

HDAPA · 28-05-12, 09:42 AM

Hello B
You may find it helpful to read the HDA fact sheet "Predictive testing for Huntington's Disease", if you have not yet done so. It is available to download from this website under "About the HDA" and then under "Online HDA Services"

Blondie · 28-05-12, 03:40 PM

I don't know the Cag repeats of my ex or his mum but he started a good ten years earlier than his MUM and our daughter a good ten years or so earlier than him.So the last 3 generations have all obviously had an increase in cag repeat I guess.From what I can gather his mum started with an average onset in her 30's and died at 46.My ex started in his early 20's and died aged just 35.My daughter has JHD.God knows what caused an average onset in his mum to pass on such an early onset in her son??We got the rarer end of the stick I guess.

just1moreperson · 28-05-12, 05:56 PM

Quote:

Originally Posted by Blondie

I don't know the Cag repeats of my ex or his mum but he started a good ten years earlier than his MUM and our daughter a good ten years or so earlier than him.So the last 3 generations have all obviously had an increase in cag repeat I guess.From what I can gather his mum started with an average onset in her 30's and died at 46.My ex started in his early 20's and died aged just 35.My daughter has JHD.God knows what caused an average onset in his mum to pass on such an early onset in her son??We got the rarer end of the stick I guess.

It sounds like the mother had a high CAG repeat herself as she developed symptoms fairly early on. It is always likely, if the gene was passed on, that it would be early onset for the next generation.

Matt